Examines 5-HT2C receptor subclass as a possible therapeutic target for the development of drugs for a range of CNS disorders such as schizophrenia, depression, drug abuse, eating disorders, Parkinson's disease and epilepsy

Updates the functional status of the 5-HT2C receptor

Written by an international group of accomplished leaders in this field

Includes supplementary material: [...]

The making of the 5-HT2C receptor.- Serotonin 5-HT2C receptors: chemical neuronatomy in the mammalian brain.- The medicinal chemistry of 5-HT2C receptor ligands.- Insights into 5-HT2C receptor function gained from transgenic mouse models.- Serotonin 5-HT2C receptor signal transduction.- Homology modeling of 5-HT2C receptors.- 5-HT2C receptor dimerization.- RNA editing of 5-HT2C receptor and neuropsychiatric diseases.- Serotonergic control of adult neurogenesis: focus on 5-HT2C receptors.- The constitutive activity of 5-HT2C receptors as an additional modality of interaction of the serotonergic system.- The 5-HT2C receptor subtype controls central dopaminergic systems: evidence from electrophysiological and neurochemical studies.- The role of serotonin-2C receptors in the pathophysiology of depression.- 5-HT2C receptors and suicidal behaviour.- The 5-HT2C receptor as a target for schizophrenia.- Serotonin and reward-related behaviour: focus on 5-HT2C receptors.- Tat-3L4F: a novel peptide for treating drug addiction by disrupting interaction between PTEN and 5-HT2C receptor.- The role of serotonin in eating behaviour: focus on 5-HT2C receptors.- Physiological and pathophysiological aspects of 5-HT2C receptors in basal ganglia.- Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment.- The role of 5-HT2A/2C receptors in sleep and waking.- Role of alternative splicing of the 5-HT2C in the Prader-Willi syndrome.- The role of 5-HT2C receptor in epilepsy.- The role of serotonin on attentional processes and executive functioning: focus on 5-HT2C receptors.- 5-HT2C receptors in learning.- The role of 5-HT2C polymorphisms in behavioural and psychological symptoms of alzheimer's disease.- Ocular hypotension: involvement of serotonergic 5-HT2C receptors.