Valerie S. Knopik; Jenae M. Neiderhiser; John C. DeFries; Robert Plomin

Genetics

ABOUT THE AUTHORSPREFACECHAPTER 1 　Overview CHAPTER 2 Historical PerspectiveThe Era of DarwinCharles DarwinFrancis GaltonBox 2.1 Francis GaltonPre-Mendelian Concepts of Heredity and VariationHeredityVariationSummaryCHAPTER 3 Mendel's Laws and Beyond Mendel’s LawsMendel’s First Law of HeredityBox 3.1 Gregor Mendel’s LuckMendel’s Second Law of HeredityBox 3.2 How Do We Know That 1 in 50 People Are Carriers for PKU?Beyond Mendel’s LawsComplex TraitsMultiple Gene InheritanceQuantitative GeneticsBox 3.3 Liability-Threshold Model of DisordersX-Chromosome: An Extension to Mendel’s LawsSummaryCHAPTER 4 The Biological Basis of HeredityDNABox 4.1 The "Central Dogma" of Molecular GeneticsChromosomesSummaryCHAPTER 5 Animal Models in Behavioral GeneticsQuantitative Genetic Experiments to Investigate Animal BehaviorSelection StudiesInbred Strain StudiesAnimal Studies for Identifying Genes and Gene FunctionsCreating MutationsQuantitative Trait LociSynteny HomologySummaryCHAPTER 6 　Nature, Nurture and Human Behavior Investigating the Genetics of Human BehaviorAdoption DesignsBox 6.1 The First Adoption Study of SchizophreniaBox 6.2 Issues in Adoption StudiesTwin DesignBox 6.3 The Twin Method 　　　Combination SummaryCHAPTER 7 Estimating Genetic and Environmental Influences HeritabilityBox 7.1 Estimating Heritability Directly from DNAInterpreting HeritabilityEnvironmentality Shared EnvironmentNonshared EnvironmentEstimating Shared and Nonshared Environmental InfluencesIdentifying Specific Nonshared EnvironmentIdentifying Specific Nonshared Environment That Predicts Behavioral OutcomesMultivariate AnalysisSummaryChapter 8 The Interplay between Genes and EnvironmentBeyond HeritabilityGenotype-Environment CorrelationThe Nature of NurtureThree Types of Genotype-Environment Correlation　　　 Three Methods to Detect Genotype-Environment Correlation　　　 ImplicationsGenotype-Environment InteractionAnimal ModelsAdoption Studies　　　 Twin StudiesDNASummaryCHAPTER 9 Identifying Genes MutationsExpanded Triplet RepeatsDetecting Polymorphisms　　　 Box 9.1 DNA MarkersHuman Behavior　　　 Linkage: Single-Gene Disorders　　　 Linkage: Complex Disorders　　　 Box 9.2 Affected Sib-Pair Linkage DesignAssociation: Candidate Genes　　　 Association: Genomewide　　　 Box 9.3 SNP MicroarraysSummaryCHAPTER 10 　Pathways between Genes and BehaviorBox 10.1 Levels of Analysis
Gene Expression and the Role of EpigeneticsThe Transcriptome: Gene Expression throughout the Genome　　　 Gene Expression Profiles: RNA Microarrays and Sequence-Based Approaches　　　　　　　 Gene Expression and Genetics　　　 Gene Expression as a Biological Basis for Environmental InfluenceThe Proteome: Proteins Coded throughout the TranscriptomeThe Brain　　　　　　　 Box 10.2 Endophenotypes　　　 Learning and Memory　　　 Neuroimaging SummaryCHAPTER 11 Cognitive Abilities Animal ResearchGeneral Cognitive AbilitySpecific Cognitive AbilitiesNeurocognitive Measures of Cognitive AbilitiesSchool AchievementThree Special Genetic Findings about Cognitive AbilitiesHeritability Increases During DevelopmentAssortative Mating is SubstantialThe same genes affect diverse cognitive and learning abilitiesIdentifying GenesSummaryCHAPTER 12 Cognitive Disabilities General Cognitive Disability: Quantitative GeneticsGeneral Cognitive Disability: Single-Gene Disorders　　　 Phenylketonuria　　　 Fragile X Syndrome　　　 Rett Syndrome　　　 Other Single-Gene DisordersGeneral Cognitive Disability: Chromosomal Abnormalities　　　 Down Syndrome　　 Sex Chromosome AbnormalitiesSmall Chromosomal DeletionsSpecific Cognitive Disabilities Reading Disability 　　　　　　　　　　　 Communication Disorders　　　 Mathematics Disability　　　 Comorbidity among Specific Cognitive DisabilitiesSummaryCHAPTER 13 Schizophrenia Box 13.1 The Beginnings of Psychiatric Genetics: Bethlem Royal and Maudsley HospitalsFamily Studies Twin StudiesAdoption StudiesSchizophrenia or Schizophrenias?Identifying GenesSummaryCHAPTER 14 Other Adult Psychopathology Mood Disorders　　　 Family Studies　　　 Twin Studies　　　　　　　 Adoption StudiesSNP-Based Heritability　　　 Identifying GenesAnxiety DisordersOther DisordersCo-Occurrence of DisordersIdentifying GenesSummaryCHAPTER 15 　Developmental PsychopathologyAutism　　　 Family and Twin Studies　　　 Identifying GenesAttention-Deficit/Hyperactivity Disorder　　　　　　　 Twin Studies　　　 Identifying GenesDistruptive Behavior DisordersAnxiety DisordersOther DisordersOverview of Twin Studies of Childhood DisordersSNP-Based Heritability Findings for Childhood DisordersSummaryCHAPTER 16 　Personality and Personality DisordersSelf-Report QuestionnairesOther Measures of PersonalityOther Findings　　　 Situations　　　 Development　　　 Nature-Nurture InterplayPersonality and Social Psychology　　　 Relationships　　　 Attitudes and Political BehaviorBehavioral EconomicsPersonality Disorders　　　 Schizotypal Personality DisorderObsessive-Compulsive Personality DisorderAntisocial Personality Disorder and Criminal BehaviorIdentifying GenesSummaryChapter 17 Substance Use Disorders Alcohol Dependence　　　　　 Twin and Adoption Research on Alcohol-Related Phenotypes　　　　　 Animal Research on Alcohol-Related PhenotypesMolecular Genetic Research on Alcohol-Related PhenotypesNicotine Dependence　　　　　 Twin Research on Smoking-Related Phenotypes　　　　　 Molecular Genetic Research on Smoking-Related PhenotypesOther DrugsComplexities of Studying the Genetics of Substance UseSummaryCHAPTER 18 　Health Psychology Health Psychology　　　　　　　 Body Weight and Obesity Subjective Well-Being and Health Health Psychology and Genetic CounselingSummaryCHAPTER 19 AgingCognitive AgingGeneral Cognitive AbilitySpecific Cognitive AbilitiesDementiaGenes and Normal Cognitive AgingHealth and AgingPhysiological FunctioningBehavioral and Physical FunctioningSelf-Rated HealthMolecular Genetics and Physical HealthLongevitySummaryCHAPTER 20 　The Future of Behavioral Genetics Quantitative GeneticsMolecular GeneticsImplications of Nature and NurtureAppendix Statistical Methods in Behavioral Genetics1. IntroductionBox A.1 Behavioral Genetic Interactive Modules1.1 Variation and Covariation: Statistical Descriptions of Individual Differences2. Quantitative Genetics2.1 The Biometric Model2.2 Estimating Variance Components3. Molecular Genetics3.1 Linkage Analysis3.2 Association Analysis
WebsitesGlossaryReferencesName Index
Subject Index