Biology and Treatment of Leukemia and Bone...

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Beschreibung

This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.

Über den Autor

Guido Marcucci, MD, is Chair and Professor in the Department of Hematologic Malignancies Translational Science and Professor in the Department of Hematology and Hematopoietic Stem Cell Transplantation at City of Hope (COH) Comprehensive Cancer Center in California. He is also Director of the Gehr Family Center for Leukemia Research at COH. Dr. Marcucci has conducted basic, translational, and clinical research in myeloid malignancies. His research focus has been on discovery of basic mechanisms of leukemogenesis, novel therapeutic targets, epigenetic and genetic prognostic biomarkers, and new drug development for AML and MDS. He has chaired several phase I, II, and III clinical trials as both single- and multi-institution studies within the oncology cooperative group Alliance (formerly known as CALGB), for which he is currently Vice-Chair of the Leukemia Committee and Member of the Leukemia Correlative Science Committee. Dr. Marcucci has published over 300 papers in peer-reviewed journals and has been uninterruptedly funded by the National Cancer Institute since 2001.

Vinod Pullarkat, MD, MRCP, is Professor in the Department of Hematology and Hematopoietic Cell Transplantation at City of Hope National Medical Center in Los Angeles, California. Dr. Pullarkat's clinical expertise is in the treatment of acute leukemia and other bone marrow neoplasms, including the use of hematopoietic stem cell transplantation. He received his medical degree from University of Calicut, India, and undertook fellowship training in Hematology/Oncology at the University of Southern California, following which he served as Faculty in the Department of Hematology and Hematopoietic Cell Transplantation at City of Hope Medical Center and at the University of Southern California. Dr. Pullarkat's research focuses especially on the biology of acute leukemia, including mechanisms of chemotherapy resistance, and the development of new therapies for acute leukemia. He has been Principal Investigator on various leukemia clinical trials and has published extensively in the fields of acute leukemia biology and therapy as well as hematopoietic stem cell transplantation.

Zusammenfassung

Offers in-depth coverage of current diagnostic and risk stratification techniques

Discusses novel treatments and pathways that may serve as targets for leukemia therapy

Provides comprehensive coverage of immunologic therapies, including hematopoietic stem cell transplantation

Inhaltsverzeichnis

Advances in diagnosis and risk stratification of leukemias and bone marrow neoplasms.- Genetics and diagnostic approach to lymphoblastic leukemia.- Acute promyelocytic leukemia: update on risk stratification and treatment.- Current and emerging therapies for AML.- Current management and new developments in treatment of ALL.- Contemporary therapy of CML.- MDS: Pathogenesis and therapy.- Chronic lymphocytic leukemia: Biology and therapy.- Biology and current treatment of Myeloproliferative neoplasms.- Systemic Mastocytosis: Pathology and treatment.- Adoptive T-cell therapy and other novel immunotherapies for leukemia.

Details

Erscheinungsjahr:	2022
Fachbereich:	Andere Fachgebiete
Genre:	Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Inhalt:	viii 196 S. 3 s/w Illustr. 14 farbige Illustr. 196 p. 17 illus. 14 illus. in color.
ISBN-13:	9783030783136
ISBN-10:	3030783138
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Marcucci, Guido Pullarkat, Vinod
Herausgeber:	Vinod Pullarkat/Guido Marcucci
Auflage:	1st edition 2021
Hersteller:	Springer International Publishing
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	235 x 155 x 12 mm
Von/Mit:	Guido Marcucci (u. a.)
Erscheinungsdatum:	10.10.2022
Gewicht:	0,318 kg

Artikel-ID: 124668827