96,65 €*
Versandkostenfrei per Post / DHL
auf Lager, Lieferzeit 1-2 Werktage
Direct comparison of enzymatic reactions and corresponding catalytic transformations in the laboratory
Bioorganic and Enzymatic Catalysis covers the most important enzymatic reactions and related catalytic bioorganic reactions using a new approach: Each enzymatic reaction type is compared with organocatalytic, organometallic and other alternative reactions, allowing the reader to understand catalytic reactions in a much-integrated way. For example, in a chapter that describes aldolases corresponding reactions using catalytic antibodies, organocatalytic reagents and metal complexes are discussed.
Written by a well-known expert in the field with more than 30 years of experience in organic and bioorganic chemistry, Bioorganic and Enzymatic Catalysis covers sample topics such as:
- Enzymatic C-C bond formation using aldolases
- Claisen-type C-C bond formation involving fatty acid synthases and polyketide synthases
- Biomimetic cyclisations involving carbenium ions
- Enzymatic oxidation and C-H activation
- Dioxygenases and oxidoreductases
With its unique approach, Bioorganic and Enzymatic Catalysis is a valuable source of information for professionals and researchers in academia and industry as well as graduate and PhD students working in the fields of organic chemistry, biochemistry, and life sciences.
Direct comparison of enzymatic reactions and corresponding catalytic transformations in the laboratory
Bioorganic and Enzymatic Catalysis covers the most important enzymatic reactions and related catalytic bioorganic reactions using a new approach: Each enzymatic reaction type is compared with organocatalytic, organometallic and other alternative reactions, allowing the reader to understand catalytic reactions in a much-integrated way. For example, in a chapter that describes aldolases corresponding reactions using catalytic antibodies, organocatalytic reagents and metal complexes are discussed.
Written by a well-known expert in the field with more than 30 years of experience in organic and bioorganic chemistry, Bioorganic and Enzymatic Catalysis covers sample topics such as:
- Enzymatic C-C bond formation using aldolases
- Claisen-type C-C bond formation involving fatty acid synthases and polyketide synthases
- Biomimetic cyclisations involving carbenium ions
- Enzymatic oxidation and C-H activation
- Dioxygenases and oxidoreductases
With its unique approach, Bioorganic and Enzymatic Catalysis is a valuable source of information for professionals and researchers in academia and industry as well as graduate and PhD students working in the fields of organic chemistry, biochemistry, and life sciences.
Wolf-D. Woggon is Emeritus Professor of Organic Chemistry in the Department of Chemistry at the University of Basel (Switzerland). He completed his PhD in organic chemistry at the University of Zurich (Switzerland) with the late Hans Schmid. After a postdoctoral stay with Alan Battersby in Cambridge (UK), he started his independent research at the University of Zurich and completed his habilitation in 1985. In 1995, he became professor at the University of Basel. His research interests include the synthesis of enzyme models, enzymatic reaction mechanisms, isolation of new enzymes, the synthesis of vitamins, metalloporphyrins, cyclodextrins and the development of new ligand-scaffolds for metal-organic catalysis. He has served for six years as head of the Department of Chemistry at the University of Basel and for further four years as its managing director.
Preface vii
1 Enzymatic C¿C Bond Formation by Aldol Reactions 1
Aldolases 1
Class I Aldolases 1
Bioorganic Class I Aldolase Reactions 3
Class II Aldolases 9
Class II Aldolase Mimics 11
References 13
2 Fatty Acid- and Polyketide-Synthases - Claisen-Type C¿C Bond Formation 15
Biomimetic Decarboxylative C¿C Bond Formation 20
References 23
3 Carbenium-Ion-Driven C¿C Bond Formations - Terpenes 25
Enzyme-like Cyclisations Involving Carbenium Ions 30
References 41
4 Oxidations Catalysed by Heme Complexes 43
Monooxygenases 43
Cytochromes P 450 45
Synthetic P450 Enzyme Models 51
Chloroperoxidase (CPO) 57
Synthetic Enzyme Mimics of Chloroperoxidase (CPO) 60
NO Synthase (NOS) 63
References 67
5 Oxidations Catalysed by Non-heme Complexes and Other Co-factors 69
Methane Monooxygenase 69
Active Site Analogues of Methane Monooxygenase 71
Enzyme Mimics of Cu Monooxygenases 75
Flavin-dependent Monooxygenases 78
Enzyme Mimics of Baeyer-Villiger Monooxygenases 83
References 95
6 C-H Activation 97
References 110
7 Dioxygenases 111
Metal Complexes Displaying Dioxygenase-like Reactivity 127
References 134
8 Oxidoreductases 137
Cytochrome c Oxidase 148
References 150
9 Synthetic Systems That Mimic Certain Aspects of Oxidoreductases 153
References 173
Index 175
Erscheinungsjahr: | 2023 |
---|---|
Fachbereich: | Populäre Darstellungen |
Genre: | Chemie, Mathematik, Medizin, Naturwissenschaften, Technik |
Rubrik: | Naturwissenschaften & Technik |
Medium: | Buch |
Inhalt: |
192 S.
11 farbige Illustr. 11 Illustr. |
ISBN-13: | 9783527336838 |
ISBN-10: | 3527336834 |
Sprache: | Englisch |
Herstellernummer: | 1133683 000 |
Einband: | Gebunden |
Autor: | Woggon, Wolf-Dietrich |
Hersteller: |
Wiley-VCH
Wiley-VCH GmbH |
Verantwortliche Person für die EU: | Wiley-VCH GmbH, Boschstr. 12, D-69469 Weinheim, product-safety@wiley.com |
Abbildungen: | 11 farbige Abbildungen |
Maße: | 246 x 174 x 15 mm |
Von/Mit: | Wolf-Dietrich Woggon |
Erscheinungsdatum: | 29.11.2023 |
Gewicht: | 0,528 kg |
Wolf-D. Woggon is Emeritus Professor of Organic Chemistry in the Department of Chemistry at the University of Basel (Switzerland). He completed his PhD in organic chemistry at the University of Zurich (Switzerland) with the late Hans Schmid. After a postdoctoral stay with Alan Battersby in Cambridge (UK), he started his independent research at the University of Zurich and completed his habilitation in 1985. In 1995, he became professor at the University of Basel. His research interests include the synthesis of enzyme models, enzymatic reaction mechanisms, isolation of new enzymes, the synthesis of vitamins, metalloporphyrins, cyclodextrins and the development of new ligand-scaffolds for metal-organic catalysis. He has served for six years as head of the Department of Chemistry at the University of Basel and for further four years as its managing director.
Preface vii
1 Enzymatic C¿C Bond Formation by Aldol Reactions 1
Aldolases 1
Class I Aldolases 1
Bioorganic Class I Aldolase Reactions 3
Class II Aldolases 9
Class II Aldolase Mimics 11
References 13
2 Fatty Acid- and Polyketide-Synthases - Claisen-Type C¿C Bond Formation 15
Biomimetic Decarboxylative C¿C Bond Formation 20
References 23
3 Carbenium-Ion-Driven C¿C Bond Formations - Terpenes 25
Enzyme-like Cyclisations Involving Carbenium Ions 30
References 41
4 Oxidations Catalysed by Heme Complexes 43
Monooxygenases 43
Cytochromes P 450 45
Synthetic P450 Enzyme Models 51
Chloroperoxidase (CPO) 57
Synthetic Enzyme Mimics of Chloroperoxidase (CPO) 60
NO Synthase (NOS) 63
References 67
5 Oxidations Catalysed by Non-heme Complexes and Other Co-factors 69
Methane Monooxygenase 69
Active Site Analogues of Methane Monooxygenase 71
Enzyme Mimics of Cu Monooxygenases 75
Flavin-dependent Monooxygenases 78
Enzyme Mimics of Baeyer-Villiger Monooxygenases 83
References 95
6 C-H Activation 97
References 110
7 Dioxygenases 111
Metal Complexes Displaying Dioxygenase-like Reactivity 127
References 134
8 Oxidoreductases 137
Cytochrome c Oxidase 148
References 150
9 Synthetic Systems That Mimic Certain Aspects of Oxidoreductases 153
References 173
Index 175
Erscheinungsjahr: | 2023 |
---|---|
Fachbereich: | Populäre Darstellungen |
Genre: | Chemie, Mathematik, Medizin, Naturwissenschaften, Technik |
Rubrik: | Naturwissenschaften & Technik |
Medium: | Buch |
Inhalt: |
192 S.
11 farbige Illustr. 11 Illustr. |
ISBN-13: | 9783527336838 |
ISBN-10: | 3527336834 |
Sprache: | Englisch |
Herstellernummer: | 1133683 000 |
Einband: | Gebunden |
Autor: | Woggon, Wolf-Dietrich |
Hersteller: |
Wiley-VCH
Wiley-VCH GmbH |
Verantwortliche Person für die EU: | Wiley-VCH GmbH, Boschstr. 12, D-69469 Weinheim, product-safety@wiley.com |
Abbildungen: | 11 farbige Abbildungen |
Maße: | 246 x 174 x 15 mm |
Von/Mit: | Wolf-Dietrich Woggon |
Erscheinungsdatum: | 29.11.2023 |
Gewicht: | 0,528 kg |