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Bioorganic and Enzymatic Catalysis
An Introduction
Buch von Wolf-Dietrich Woggon
Sprache: Englisch

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Beschreibung

Direct comparison of enzymatic reactions and corresponding catalytic transformations in the laboratory

Bioorganic and Enzymatic Catalysis covers the most important enzymatic reactions and related catalytic bioorganic reactions using a new approach: Each enzymatic reaction type is compared with organocatalytic, organometallic and other alternative reactions, allowing the reader to understand catalytic reactions in a much-integrated way. For example, in a chapter that describes aldolases corresponding reactions using catalytic antibodies, organocatalytic reagents and metal complexes are discussed.

Written by a well-known expert in the field with more than 30 years of experience in organic and bioorganic chemistry, Bioorganic and Enzymatic Catalysis covers sample topics such as:

  • Enzymatic C-C bond formation using aldolases
  • Claisen-type C-C bond formation involving fatty acid synthases and polyketide synthases
  • Biomimetic cyclisations involving carbenium ions
  • Enzymatic oxidation and C-H activation
  • Dioxygenases and oxidoreductases

With its unique approach, Bioorganic and Enzymatic Catalysis is a valuable source of information for professionals and researchers in academia and industry as well as graduate and PhD students working in the fields of organic chemistry, biochemistry, and life sciences.

Direct comparison of enzymatic reactions and corresponding catalytic transformations in the laboratory

Bioorganic and Enzymatic Catalysis covers the most important enzymatic reactions and related catalytic bioorganic reactions using a new approach: Each enzymatic reaction type is compared with organocatalytic, organometallic and other alternative reactions, allowing the reader to understand catalytic reactions in a much-integrated way. For example, in a chapter that describes aldolases corresponding reactions using catalytic antibodies, organocatalytic reagents and metal complexes are discussed.

Written by a well-known expert in the field with more than 30 years of experience in organic and bioorganic chemistry, Bioorganic and Enzymatic Catalysis covers sample topics such as:

  • Enzymatic C-C bond formation using aldolases
  • Claisen-type C-C bond formation involving fatty acid synthases and polyketide synthases
  • Biomimetic cyclisations involving carbenium ions
  • Enzymatic oxidation and C-H activation
  • Dioxygenases and oxidoreductases

With its unique approach, Bioorganic and Enzymatic Catalysis is a valuable source of information for professionals and researchers in academia and industry as well as graduate and PhD students working in the fields of organic chemistry, biochemistry, and life sciences.

Über den Autor

Wolf-D. Woggon is Emeritus Professor of Organic Chemistry in the Department of Chemistry at the University of Basel (Switzerland). He completed his PhD in organic chemistry at the University of Zurich (Switzerland) with the late Hans Schmid. After a postdoctoral stay with Alan Battersby in Cambridge (UK), he started his independent research at the University of Zurich and completed his habilitation in 1985. In 1995, he became professor at the University of Basel. His research interests include the synthesis of enzyme models, enzymatic reaction mechanisms, isolation of new enzymes, the synthesis of vitamins, metalloporphyrins, cyclodextrins and the development of new ligand-scaffolds for metal-organic catalysis. He has served for six years as head of the Department of Chemistry at the University of Basel and for further four years as its managing director.

Inhaltsverzeichnis

Preface vii

1 Enzymatic C¿C Bond Formation by Aldol Reactions 1

Aldolases 1

Class I Aldolases 1

Bioorganic Class I Aldolase Reactions 3

Class II Aldolases 9

Class II Aldolase Mimics 11

References 13

2 Fatty Acid- and Polyketide-Synthases - Claisen-Type C¿C Bond Formation 15

Biomimetic Decarboxylative C¿C Bond Formation 20

References 23

3 Carbenium-Ion-Driven C¿C Bond Formations - Terpenes 25

Enzyme-like Cyclisations Involving Carbenium Ions 30

References 41

4 Oxidations Catalysed by Heme Complexes 43

Monooxygenases 43

Cytochromes P 450 45

Synthetic P450 Enzyme Models 51

Chloroperoxidase (CPO) 57

Synthetic Enzyme Mimics of Chloroperoxidase (CPO) 60

NO Synthase (NOS) 63

References 67

5 Oxidations Catalysed by Non-heme Complexes and Other Co-factors 69

Methane Monooxygenase 69

Active Site Analogues of Methane Monooxygenase 71

Enzyme Mimics of Cu Monooxygenases 75

Flavin-dependent Monooxygenases 78

Enzyme Mimics of Baeyer-Villiger Monooxygenases 83

References 95

6 C-H Activation 97

References 110

7 Dioxygenases 111

Metal Complexes Displaying Dioxygenase-like Reactivity 127

References 134

8 Oxidoreductases 137

Cytochrome c Oxidase 148

References 150

9 Synthetic Systems That Mimic Certain Aspects of Oxidoreductases 153

References 173

Index 175

Details
Erscheinungsjahr: 2023
Fachbereich: Populäre Darstellungen
Genre: Chemie, Mathematik, Medizin, Naturwissenschaften, Technik
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Inhalt: 192 S.
11 farbige Illustr.
11 Illustr.
ISBN-13: 9783527336838
ISBN-10: 3527336834
Sprache: Englisch
Herstellernummer: 1133683 000
Einband: Gebunden
Autor: Woggon, Wolf-Dietrich
Hersteller: Wiley-VCH
Wiley-VCH GmbH
Verantwortliche Person für die EU: Wiley-VCH GmbH, Boschstr. 12, D-69469 Weinheim, product-safety@wiley.com
Abbildungen: 11 farbige Abbildungen
Maße: 246 x 174 x 15 mm
Von/Mit: Wolf-Dietrich Woggon
Erscheinungsdatum: 29.11.2023
Gewicht: 0,528 kg
Artikel-ID: 126785743
Über den Autor

Wolf-D. Woggon is Emeritus Professor of Organic Chemistry in the Department of Chemistry at the University of Basel (Switzerland). He completed his PhD in organic chemistry at the University of Zurich (Switzerland) with the late Hans Schmid. After a postdoctoral stay with Alan Battersby in Cambridge (UK), he started his independent research at the University of Zurich and completed his habilitation in 1985. In 1995, he became professor at the University of Basel. His research interests include the synthesis of enzyme models, enzymatic reaction mechanisms, isolation of new enzymes, the synthesis of vitamins, metalloporphyrins, cyclodextrins and the development of new ligand-scaffolds for metal-organic catalysis. He has served for six years as head of the Department of Chemistry at the University of Basel and for further four years as its managing director.

Inhaltsverzeichnis

Preface vii

1 Enzymatic C¿C Bond Formation by Aldol Reactions 1

Aldolases 1

Class I Aldolases 1

Bioorganic Class I Aldolase Reactions 3

Class II Aldolases 9

Class II Aldolase Mimics 11

References 13

2 Fatty Acid- and Polyketide-Synthases - Claisen-Type C¿C Bond Formation 15

Biomimetic Decarboxylative C¿C Bond Formation 20

References 23

3 Carbenium-Ion-Driven C¿C Bond Formations - Terpenes 25

Enzyme-like Cyclisations Involving Carbenium Ions 30

References 41

4 Oxidations Catalysed by Heme Complexes 43

Monooxygenases 43

Cytochromes P 450 45

Synthetic P450 Enzyme Models 51

Chloroperoxidase (CPO) 57

Synthetic Enzyme Mimics of Chloroperoxidase (CPO) 60

NO Synthase (NOS) 63

References 67

5 Oxidations Catalysed by Non-heme Complexes and Other Co-factors 69

Methane Monooxygenase 69

Active Site Analogues of Methane Monooxygenase 71

Enzyme Mimics of Cu Monooxygenases 75

Flavin-dependent Monooxygenases 78

Enzyme Mimics of Baeyer-Villiger Monooxygenases 83

References 95

6 C-H Activation 97

References 110

7 Dioxygenases 111

Metal Complexes Displaying Dioxygenase-like Reactivity 127

References 134

8 Oxidoreductases 137

Cytochrome c Oxidase 148

References 150

9 Synthetic Systems That Mimic Certain Aspects of Oxidoreductases 153

References 173

Index 175

Details
Erscheinungsjahr: 2023
Fachbereich: Populäre Darstellungen
Genre: Chemie, Mathematik, Medizin, Naturwissenschaften, Technik
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Inhalt: 192 S.
11 farbige Illustr.
11 Illustr.
ISBN-13: 9783527336838
ISBN-10: 3527336834
Sprache: Englisch
Herstellernummer: 1133683 000
Einband: Gebunden
Autor: Woggon, Wolf-Dietrich
Hersteller: Wiley-VCH
Wiley-VCH GmbH
Verantwortliche Person für die EU: Wiley-VCH GmbH, Boschstr. 12, D-69469 Weinheim, product-safety@wiley.com
Abbildungen: 11 farbige Abbildungen
Maße: 246 x 174 x 15 mm
Von/Mit: Wolf-Dietrich Woggon
Erscheinungsdatum: 29.11.2023
Gewicht: 0,528 kg
Artikel-ID: 126785743
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