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While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process.
Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life.
In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns.
Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.
While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process.
Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life.
In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns.
Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.
Gathers recent research on developmental programming and age-related disease
Expert contributors describe the developmental origins of adult health and disease
Benefits gerontology scholars, researchers, and clinicians, as well as the general public
SECTION I OVERVIEW.- Introductory chapter.- SECTION II EXPERIMENTAL STUDY OF DOHAD.- Early Life Programming of Aging in Genetically Long-Lived Mice.- Immunological Basis of In Utero Programming of Adult Disease.- Developmental Programming of the GH/IGF Axis and Long Term Health.- Programming of Stress Responses.- Early-life Nutritional Programming of Adult Health Status.- Effects of In-Utero Conditions on Adult Feeding Preferences.- IUGR-Related Programming of Metabolic Syndrome and Type 2 Diabetes.- Early-life Programming of Osteoporosis.- Developmental Epigenetic Programming of Skeletal Muscle Aging.- Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease..- Developmental Programming of Neuroimmune Function.- Epigenetics and neurodegeneration: role of early-life nutrition.- SECTION III EPIDEMIOLOGICAL EVIDENCE.- Prenatal Undernutrition and Ageing and Longevity.- Influence of Maternal Obesity on the Long-Term Healthof Offspring.- Early Life Predictors of Women's Health and Ageing.- Early-Life Predictors of Exceptional Longevity.- Prenatal Undernutrition and Effects on Physical and Mental Health.- Ancestral and early origins of adult mortality - a multigenerational approach.- SECTION IV PERSPECTIVES AND IMPLICATIONS.- Social Policy and Public Health Perspectives of DOHaD: Implications for Policy Advocacy, Cross-Sectorial Collaboration and Health Promotion.- Index.
| Erscheinungsjahr: | 2019 |
|---|---|
| Fachbereich: | Andere Fachgebiete |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Reihe: | Healthy Ageing and Longevity |
| Inhalt: |
xi
310 S. 10 s/w Illustr. 17 farbige Illustr. 310 p. 27 illus. 17 illus. in color. |
| ISBN-13: | 9783030249571 |
| ISBN-10: | 3030249573 |
| Sprache: | Englisch |
| Ausstattung / Beilage: | HC runder Rücken kaschiert |
| Einband: | Gebunden |
| Autor: | Vaiserman, Alexander |
| Redaktion: | Vaiserman, Alexander |
| Herausgeber: | Alexander Vaiserman |
| Auflage: | 1st ed. 2019 |
| Hersteller: |
Springer International Publishing
Springer International Publishing AG Healthy Ageing and Longevity |
| Maße: | 241 x 160 x 24 mm |
| Von/Mit: | Alexander Vaiserman |
| Erscheinungsdatum: | 12.08.2019 |
| Gewicht: | 0,653 kg |
Gathers recent research on developmental programming and age-related disease
Expert contributors describe the developmental origins of adult health and disease
Benefits gerontology scholars, researchers, and clinicians, as well as the general public
SECTION I OVERVIEW.- Introductory chapter.- SECTION II EXPERIMENTAL STUDY OF DOHAD.- Early Life Programming of Aging in Genetically Long-Lived Mice.- Immunological Basis of In Utero Programming of Adult Disease.- Developmental Programming of the GH/IGF Axis and Long Term Health.- Programming of Stress Responses.- Early-life Nutritional Programming of Adult Health Status.- Effects of In-Utero Conditions on Adult Feeding Preferences.- IUGR-Related Programming of Metabolic Syndrome and Type 2 Diabetes.- Early-life Programming of Osteoporosis.- Developmental Epigenetic Programming of Skeletal Muscle Aging.- Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease..- Developmental Programming of Neuroimmune Function.- Epigenetics and neurodegeneration: role of early-life nutrition.- SECTION III EPIDEMIOLOGICAL EVIDENCE.- Prenatal Undernutrition and Ageing and Longevity.- Influence of Maternal Obesity on the Long-Term Healthof Offspring.- Early Life Predictors of Women's Health and Ageing.- Early-Life Predictors of Exceptional Longevity.- Prenatal Undernutrition and Effects on Physical and Mental Health.- Ancestral and early origins of adult mortality - a multigenerational approach.- SECTION IV PERSPECTIVES AND IMPLICATIONS.- Social Policy and Public Health Perspectives of DOHaD: Implications for Policy Advocacy, Cross-Sectorial Collaboration and Health Promotion.- Index.
| Erscheinungsjahr: | 2019 |
|---|---|
| Fachbereich: | Andere Fachgebiete |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Reihe: | Healthy Ageing and Longevity |
| Inhalt: |
xi
310 S. 10 s/w Illustr. 17 farbige Illustr. 310 p. 27 illus. 17 illus. in color. |
| ISBN-13: | 9783030249571 |
| ISBN-10: | 3030249573 |
| Sprache: | Englisch |
| Ausstattung / Beilage: | HC runder Rücken kaschiert |
| Einband: | Gebunden |
| Autor: | Vaiserman, Alexander |
| Redaktion: | Vaiserman, Alexander |
| Herausgeber: | Alexander Vaiserman |
| Auflage: | 1st ed. 2019 |
| Hersteller: |
Springer International Publishing
Springer International Publishing AG Healthy Ageing and Longevity |
| Maße: | 241 x 160 x 24 mm |
| Von/Mit: | Alexander Vaiserman |
| Erscheinungsdatum: | 12.08.2019 |
| Gewicht: | 0,653 kg |
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