Provides new perspectives towards addressing problems faced by patients, practitioners, healthcare researchers, and health system managers

Provides the latest insights of applying systems and complexity sciences to healthcare services, physiological basis of health and disease, health professional education, and health system redesign

Features authorship of experienced practitioners and researchers in their respective fields

Introduction.- Max Planck's Challenge for Health, Health Care and the Healthcare System.- Fail Small, Fail Often: An Outsider's View of Physiologic Complexity.- Physiology.- A Puzzling Question: How Can Different Phenotypes Possibly Have Indistinguishable Disease Symptoms?.- Complexity Sciences Dramatically Improve Biomarker Research and Use.- Analyzing Complex Medical Image Information: Convolution versus Wavelets in a Neural Net.- The Mechanisms of How Genomic Heterogeneity Impacts Bio-Emergent Properties: The Challenges for Precision Medicine.- Health Care.- The Health System Quartet: Four Basic Systems-Cure, Care, Heal, and Deal-to Foster the Co-Production of Sustained Health.- Humans and Big Data-New Hope? Harnessing the Power of Person-Centered Data Analytics.- Is Decision-making of Women Concerning their Violent Relationships Truly Nonlinear... and Why Is That?.- Co-Producing Health Care Interventions: Transforming Transdisciplinary Research to Develop Health Care Service to Meet the Needs of Patients with Complex Problems.- Education & Leadership.- Coordinated Tension: The "Secret Sauce" to Enable Decision Making in a Global Health Complex Adaptive System.- A Systems Perspective for Measuring Features of Transdisciplinary Knowledge Producing Teams (TDKPTs).- How and Why Effective Leaders Construct and Evolve Structural Attractors to Overcome Spatial, Temporal and Social Complexity.- Physician Burnout: A U.S. Public Health Crisis in Need of a Socio-Ecological Solution.- Health Systems & Policy.- Organisational Relativity-Changing Our Perspective on Health and Healthcare.- A Systems Model of HIT Induced Complexity.- Salutogenesis Revisited.- Disappointment-Driven System-Improvement in Healthcare.- A Study on the Modeling of Obesity. The Programme.