Emerging Concepts of Tumor Exosome¿Mediate...

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Beschreibung

In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.

Zusammenfassung

Explores recent findings on vesicle-based information transfer by exosomes

Provides an overview of exosomes biology and function

Discusses the role of exosomal tetraspanins in tumor progression

Includes supplementary material: [...]

Inhaltsverzeichnis

Preface.- The Cell Biology of Exosomes : Historical and Perspectives.- The role of exosomal shuttle RNA (esRNA) in cell-to-cell.- Exosomal lipids in cell-cell communication.- The Functional Importance Of Tetraspanins In Exosomes.- The effects of exosomes and related vesicles on cancer development, progression, and dissemination.- Circulating Cell-derived Vesicles Mediate Tumor Progression.- Immune modulation of T cells and natural killer cells by tumor-derived exosomes.- The Role Of Tumor Exosomes In Tumorigenicity.- Microenvironmental regulation of metastasis by exosomes.- Microvesicles and their Emerging Role in Cellular Therapies for Organ and Tissue Regeneration.- Index

Details

Erscheinungsjahr:	2012
Fachbereich:	Therapie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	viii 220 S.
ISBN-13:	9781461436966
ISBN-10:	1461436966
Sprache:	Englisch
Herstellernummer:	80065494
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Zhang, Huang-Ge
Herausgeber:	Huang-Ge Zhang
Hersteller:	Springer US Springer New York Springer US, New York, N.Y.
Maße:	241 x 160 x 17 mm
Von/Mit:	Huang-Ge Zhang
Erscheinungsdatum:	06.09.2012
Gewicht:	0,512 kg

Artikel-ID: 106600342