Section I. Introduction to Mitochondrial Diseases
1. Mitochondrial disease in neurology - Past, present, and future

Section II. Most Common Neurological Manifestations of Mitochondrial Disease
2. Progressive external ophthalmoplegia
3. Mitochondrial optic neuropathies
4. Leigh syndrome
5. Stroke-like episodes in adult mitochondrial disease
6. Ataxia and spastic paraplegia in mitochondrial disease
7. Peripheral neuropathy in mitochondrial disease
8. Complex neurological and multisystem presentations in mitochondrial disease

Section III. Diagnosing Mitochondrial Disease
9. Investigation of oxidative phosphorylation activity and composition in mitochondrial disease
10. Genetics of mitochondrial diseases: Current approaches for the molecular diagnosis
11. Laboratory and metabolic investigations
12. Neuroimaging in mitochondrial disease

Section IV. Therapy and Future Challenges
13. Currently available therapies in mitochondrial disease
14. Reproductive options in mitochondrial disease
15. Clinical trials in mitochondrial disease
16. Blood biomarkers of mitochondrial disease - One for all or all for one?
17. Experimental therapy for mitochondrial diseases