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Multiple Testing Procedures with Applications to Genomics
Taschenbuch von Mark J. Van Der Laan (u. a.)
Sprache: Englisch

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Beschreibung
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
Zusammenfassung
This book provides a detailed account of the theoretical foundations of proposed multiple testing methods and illustrates their application to a range of testing problems in genomics.
Inhaltsverzeichnis
Multiple Hypothesis Testing.- Test Statistics Null Distribution.- Overview of Multiple Testing Procedures.- Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn).- Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate.- Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Simulation Studies: Assessment of Test Statistics Null Distributions.- Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments.- Multiple Tests of Association with Biological Annotation Metadata.- HIV-1 Sequence Variation and Viral Replication Capacity.- Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project.- Software Implementation.
Details
Erscheinungsjahr: 2010
Fachbereich: Allgemeines
Genre: Biologie, Importe
Rubrik: Naturwissenschaften & Technik
Medium: Taschenbuch
Reihe: Springer Series in Statistics
Inhalt: xxxiii
590 S.
61 s/w Illustr.
24 farbige Illustr.
ISBN-13: 9781441923790
ISBN-10: 1441923799
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Laan, Mark J. Van Der
Dudoit, Sandrine
Auflage: Softcover reprint of hardcover 1st ed. 2008
Hersteller: Springer US
Springer New York
Springer Series in Statistics
Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße: 235 x 155 x 34 mm
Von/Mit: Mark J. Van Der Laan (u. a.)
Erscheinungsdatum: 25.11.2010
Gewicht: 0,931 kg
Artikel-ID: 107253073
Zusammenfassung
This book provides a detailed account of the theoretical foundations of proposed multiple testing methods and illustrates their application to a range of testing problems in genomics.
Inhaltsverzeichnis
Multiple Hypothesis Testing.- Test Statistics Null Distribution.- Overview of Multiple Testing Procedures.- Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn).- Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate.- Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Simulation Studies: Assessment of Test Statistics Null Distributions.- Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments.- Multiple Tests of Association with Biological Annotation Metadata.- HIV-1 Sequence Variation and Viral Replication Capacity.- Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project.- Software Implementation.
Details
Erscheinungsjahr: 2010
Fachbereich: Allgemeines
Genre: Biologie, Importe
Rubrik: Naturwissenschaften & Technik
Medium: Taschenbuch
Reihe: Springer Series in Statistics
Inhalt: xxxiii
590 S.
61 s/w Illustr.
24 farbige Illustr.
ISBN-13: 9781441923790
ISBN-10: 1441923799
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Laan, Mark J. Van Der
Dudoit, Sandrine
Auflage: Softcover reprint of hardcover 1st ed. 2008
Hersteller: Springer US
Springer New York
Springer Series in Statistics
Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße: 235 x 155 x 34 mm
Von/Mit: Mark J. Van Der Laan (u. a.)
Erscheinungsdatum: 25.11.2010
Gewicht: 0,931 kg
Artikel-ID: 107253073
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