Peter Hindmarsh is a Professor of Pediatric Endocrinology in London, United Kingdom. He has published extensively on cortisol physiology and pharmacology and how these impact on replacement therapies for adrenal insufficiency. He is interested in better delivery of treatment in a more physiological manner as exemplified by the delivery of hydrocortisone using pump therapy to mimic the circadian rhythm.

1. Why do we need to get hydrocortisone replacement right?
2. Mortality and morbidity data
3. Side effects and survey results of quality of life
4. Oral Glucocorticoid replacement
5. What is dosing regimen
6. How to calculate daily dose
7. How to distribute the dose
8. Drug interactions including drugs that alter liver metabolism
9. Specific problems with hormone replacement - oral or transdermal estrogens
10. Interplay of cortisol and vasopressin - diagnosis of diabetes insipidus and DDAVP replacement
11. Pituitary replacement that may modify hydrocortisone dosing - thyroxine and growth hormone
12. Monitoring replacement
13. What's missing what are we replacing what should we check
14. Ways of checking 17OHP, ACTH cortisol
15. Single sample versus multiple samples
16. Around dose sampling
17. Effects of OCP
18. Adjusting doses for events
19. Illness and the boxes
20. Stressful events
21. Surgery
22. Dental and the boxes
23. Travel and time zones
24. Adjustments and effects on other hormones e.g. DDAVP
25. Glucocorticoid replacement using pump therapy
26. Pump therapy to mimic circadian rhythm
27. Principles of the pump
28. Setting the system up, clearance studies
29. Monitoring replacement
30. Quality of life
31. Managing an Adrenal Crisis
32. Presentation as new diagnosis or following diagnosis
33. What it is and what it is not
34. Biochemical changes
35. How to manage a crisis - at home, in A&E after admission
36. Hydrocortisone requirements in a crisis
37. Glucose requirements during a crisis
38. Sodium and fluid balance - the importance of subacute or chronic hyponatraemia
39. Hyperkalaemia
40. Weaning Glucocorticoids
41. Factors influencing adrenal suppression dose, type of steroid, how long given, potency and whether given during day or night
42. The role of alternate day treatments
43. Principles in weaning
44. How to wean depending on duration of exposure, disease activity steroid used
45. What tests to use to determine axis recovery