Jan Barciszewski is Professor at Adam Mickiewicz University (AMU) in Poznä, Poland, and at the Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznä, Poland, where he has worked since 1974. He studied organic chemistry at the AMU. During his Ph.D. studies, he worked on the structure and function of modified bases and nucleoside sequences of plant phenylalanine-specific transfer ribonucleic acid (tRNA), including cytokinins. He was subsequently granted Doctor of Science degree for his work on the properties of plant tRNAs and aminoacyl-tRNA synthetases. In the 1990s, he began working on the diagnosis and therapy of brain tumors. He developed a new method for the transformation of plant mitochondria based on catalytic RNAs and is currently involved in studies on a new type of catalytic RNAs (enantiomeric ribozymes) for efficient RNA target cleavage in vivo, as well as the search for new anti-aging agents.

Provides a complete picture of the latest findings in RNA structure and function

Inspires researchers and students with applications of latest technologies in the field

Describes the role of RNA in basic biological processes and disorders, such as cancer

1. Computational Tools for Functional Analysis of Circular RNAs.- 2. The Hidden Layer of RNA Variants.- 3. Functional Role of Non-Coding RNAs in Prostate Cancer: From Biomarker to Therapeutic Targets.- 4. The structure, function, and modification of non-coding RNAs in cardiovascular system,- 5. Contribution of RNA Species in Sexually Transmitted Infections.- 6. Hypoxia and Epithelial-to-Mesenchymal Transition (EMT) in Cancer: A Non-Coding RNA Perspective.- 6. A Study on the Role of piRNAs in Cancer Epigenetics.- 7. Modified Nucleosides as RNA Components. Structure, Biological Role and Drug Design.- 8. Multifaceted Functions of RNA m6A Modification in Modulating Regulated Cell Death.- 9. Incorporation of Pseudouridine into RNA for Biochemical and Biophysical Studies.- 10. Molecular Dynamics Simulations of Chemically Modified Ribonucleotides.