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This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.
Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approachesin the field today.
Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approachesin the field today.
This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.
Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approachesin the field today.
Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approachesin the field today.
Zusammenfassung
Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Inhaltsverzeichnis
1. From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling
Dirk M. Hermann and Thorsten R. Doeppner
2. How to Avoid Bumping into the Translational Roadblock
Malcolm Macleod and Emily Sena
3. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview Vincent Prinz and Matthias Endres
4. Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture
Ludmila Belayev, Matthias Endres, and Vincent Prinz
5. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding devices and Endothelin-1
I Mhairi Macrae
6. Mouse Model of in situ Thromboembolic Stroke and Reperfusion
Orset Cyrille, Le Béhot Audrey, Bonnet Anne-Laure, Maysami Samaneh, and Vivien Denis
7. Photochemical Models of Focal Brain Ischemia
Anja Urbach and Otto W. Witte
<
8. Housing in an Enriched Environment ¿ A Tool to Study Functional Recovery after Experimental Stroke
Karsten Ruscher and Tadeusz Wieloch
9. Modeling Risk Factors and Confounding Effects in Stroke
Barry McColl, David Howells, Nancy Rothwell, and Adam Denes
10. Effect of Anesthesia in Stroke Models
Richard J. Traystman<
11. Non-invasive Brain Imaging in Small Animal Stroke Models: MRI, PET and SPECT
Abraham Martín, Pedro Ramos-Cabrer, and Anna M. Planas
12. Non-invasive Optical Imaging in Rodent Models of Stroke Markus Vaas and Jan Klohs
13. Behavioral Testing in Rodent Models of Stroke, Part I
René Bernard, Mustafa Balkaya, and André Rex
14. Behavioral Testing in Rodent Models of Stroke ¿Part II
Gerlinde A.S. Metz
15. Combining Classical Comprehensive With Ethological Based, High Throughput Automated Behavioral Phenotyping for Rodent Models of Stroke
Anne-Christine Plank, Stephan von Hörsten, and Fabio Canneva
16. Histology and Infarct Volume Determination in Rodent Models of Stroke
Clemens Sommer
17. Ethics of Modeling of Cerebral Ischemia in Small Animals
Ute Lindauer
18. Quality Control and Standard Operating Procedures
Ulrich Dirnagl
19. Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing
Ulrich Dirnagl
20. Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers Ulrich Dirnagl
Dirk M. Hermann and Thorsten R. Doeppner
2. How to Avoid Bumping into the Translational Roadblock
Malcolm Macleod and Emily Sena
3. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview Vincent Prinz and Matthias Endres
4. Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture
Ludmila Belayev, Matthias Endres, and Vincent Prinz
5. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding devices and Endothelin-1
I Mhairi Macrae
6. Mouse Model of in situ Thromboembolic Stroke and Reperfusion
Orset Cyrille, Le Béhot Audrey, Bonnet Anne-Laure, Maysami Samaneh, and Vivien Denis
7. Photochemical Models of Focal Brain Ischemia
Anja Urbach and Otto W. Witte
<
8. Housing in an Enriched Environment ¿ A Tool to Study Functional Recovery after Experimental Stroke
Karsten Ruscher and Tadeusz Wieloch
9. Modeling Risk Factors and Confounding Effects in Stroke
Barry McColl, David Howells, Nancy Rothwell, and Adam Denes
10. Effect of Anesthesia in Stroke Models
Richard J. Traystman<
11. Non-invasive Brain Imaging in Small Animal Stroke Models: MRI, PET and SPECT
Abraham Martín, Pedro Ramos-Cabrer, and Anna M. Planas
12. Non-invasive Optical Imaging in Rodent Models of Stroke Markus Vaas and Jan Klohs
13. Behavioral Testing in Rodent Models of Stroke, Part I
René Bernard, Mustafa Balkaya, and André Rex
14. Behavioral Testing in Rodent Models of Stroke ¿Part II
Gerlinde A.S. Metz
15. Combining Classical Comprehensive With Ethological Based, High Throughput Automated Behavioral Phenotyping for Rodent Models of Stroke
Anne-Christine Plank, Stephan von Hörsten, and Fabio Canneva
16. Histology and Infarct Volume Determination in Rodent Models of Stroke
Clemens Sommer
17. Ethics of Modeling of Cerebral Ischemia in Small Animals
Ute Lindauer
18. Quality Control and Standard Operating Procedures
Ulrich Dirnagl
19. Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing
Ulrich Dirnagl
20. Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers Ulrich Dirnagl
Details
Erscheinungsjahr: | 2018 |
---|---|
Fachbereich: | Therapie |
Genre: | Medizin |
Rubrik: | Wissenschaften |
Medium: | Taschenbuch |
Reihe: | Neuromethods |
Inhalt: |
xii
338 S. 7 s/w Illustr. 54 farbige Illustr. 338 p. 61 illus. 54 illus. in color. |
ISBN-13: | 9781493981670 |
ISBN-10: | 1493981676 |
Sprache: | Englisch |
Ausstattung / Beilage: | Paperback |
Einband: | Kartoniert / Broschiert |
Redaktion: | Dirnagl, Ulrich |
Herausgeber: | Ulrich Dirnagl |
Auflage: | Softcover reprint of the original 2nd ed. 2016 |
Hersteller: |
Springer New York
Springer US, New York, N.Y. Neuromethods |
Maße: | 254 x 178 x 20 mm |
Von/Mit: | Ulrich Dirnagl |
Erscheinungsdatum: | 21.04.2018 |
Gewicht: | 0,663 kg |
Zusammenfassung
Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Inhaltsverzeichnis
1. From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling
Dirk M. Hermann and Thorsten R. Doeppner
2. How to Avoid Bumping into the Translational Roadblock
Malcolm Macleod and Emily Sena
3. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview Vincent Prinz and Matthias Endres
4. Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture
Ludmila Belayev, Matthias Endres, and Vincent Prinz
5. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding devices and Endothelin-1
I Mhairi Macrae
6. Mouse Model of in situ Thromboembolic Stroke and Reperfusion
Orset Cyrille, Le Béhot Audrey, Bonnet Anne-Laure, Maysami Samaneh, and Vivien Denis
7. Photochemical Models of Focal Brain Ischemia
Anja Urbach and Otto W. Witte
<
8. Housing in an Enriched Environment ¿ A Tool to Study Functional Recovery after Experimental Stroke
Karsten Ruscher and Tadeusz Wieloch
9. Modeling Risk Factors and Confounding Effects in Stroke
Barry McColl, David Howells, Nancy Rothwell, and Adam Denes
10. Effect of Anesthesia in Stroke Models
Richard J. Traystman<
11. Non-invasive Brain Imaging in Small Animal Stroke Models: MRI, PET and SPECT
Abraham Martín, Pedro Ramos-Cabrer, and Anna M. Planas
12. Non-invasive Optical Imaging in Rodent Models of Stroke Markus Vaas and Jan Klohs
13. Behavioral Testing in Rodent Models of Stroke, Part I
René Bernard, Mustafa Balkaya, and André Rex
14. Behavioral Testing in Rodent Models of Stroke ¿Part II
Gerlinde A.S. Metz
15. Combining Classical Comprehensive With Ethological Based, High Throughput Automated Behavioral Phenotyping for Rodent Models of Stroke
Anne-Christine Plank, Stephan von Hörsten, and Fabio Canneva
16. Histology and Infarct Volume Determination in Rodent Models of Stroke
Clemens Sommer
17. Ethics of Modeling of Cerebral Ischemia in Small Animals
Ute Lindauer
18. Quality Control and Standard Operating Procedures
Ulrich Dirnagl
19. Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing
Ulrich Dirnagl
20. Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers Ulrich Dirnagl
Dirk M. Hermann and Thorsten R. Doeppner
2. How to Avoid Bumping into the Translational Roadblock
Malcolm Macleod and Emily Sena
3. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview Vincent Prinz and Matthias Endres
4. Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture
Ludmila Belayev, Matthias Endres, and Vincent Prinz
5. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding devices and Endothelin-1
I Mhairi Macrae
6. Mouse Model of in situ Thromboembolic Stroke and Reperfusion
Orset Cyrille, Le Béhot Audrey, Bonnet Anne-Laure, Maysami Samaneh, and Vivien Denis
7. Photochemical Models of Focal Brain Ischemia
Anja Urbach and Otto W. Witte
<
8. Housing in an Enriched Environment ¿ A Tool to Study Functional Recovery after Experimental Stroke
Karsten Ruscher and Tadeusz Wieloch
9. Modeling Risk Factors and Confounding Effects in Stroke
Barry McColl, David Howells, Nancy Rothwell, and Adam Denes
10. Effect of Anesthesia in Stroke Models
Richard J. Traystman<
11. Non-invasive Brain Imaging in Small Animal Stroke Models: MRI, PET and SPECT
Abraham Martín, Pedro Ramos-Cabrer, and Anna M. Planas
12. Non-invasive Optical Imaging in Rodent Models of Stroke Markus Vaas and Jan Klohs
13. Behavioral Testing in Rodent Models of Stroke, Part I
René Bernard, Mustafa Balkaya, and André Rex
14. Behavioral Testing in Rodent Models of Stroke ¿Part II
Gerlinde A.S. Metz
15. Combining Classical Comprehensive With Ethological Based, High Throughput Automated Behavioral Phenotyping for Rodent Models of Stroke
Anne-Christine Plank, Stephan von Hörsten, and Fabio Canneva
16. Histology and Infarct Volume Determination in Rodent Models of Stroke
Clemens Sommer
17. Ethics of Modeling of Cerebral Ischemia in Small Animals
Ute Lindauer
18. Quality Control and Standard Operating Procedures
Ulrich Dirnagl
19. Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing
Ulrich Dirnagl
20. Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers Ulrich Dirnagl
Details
Erscheinungsjahr: | 2018 |
---|---|
Fachbereich: | Therapie |
Genre: | Medizin |
Rubrik: | Wissenschaften |
Medium: | Taschenbuch |
Reihe: | Neuromethods |
Inhalt: |
xii
338 S. 7 s/w Illustr. 54 farbige Illustr. 338 p. 61 illus. 54 illus. in color. |
ISBN-13: | 9781493981670 |
ISBN-10: | 1493981676 |
Sprache: | Englisch |
Ausstattung / Beilage: | Paperback |
Einband: | Kartoniert / Broschiert |
Redaktion: | Dirnagl, Ulrich |
Herausgeber: | Ulrich Dirnagl |
Auflage: | Softcover reprint of the original 2nd ed. 2016 |
Hersteller: |
Springer New York
Springer US, New York, N.Y. Neuromethods |
Maße: | 254 x 178 x 20 mm |
Von/Mit: | Ulrich Dirnagl |
Erscheinungsdatum: | 21.04.2018 |
Gewicht: | 0,663 kg |
Warnhinweis