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Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.
Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.
Über den Autor
Haresh Chaudhary has completed [...] and [...] from Shri Sarvajanik Pharmacy College,Mehsana and currently working in Formulation Development Department at Cadila Healthcare Ltd, Ahmedabad. He is energetic person with positive attitude toward his goal.
Details
Erscheinungsjahr: | 2014 |
---|---|
Fachbereich: | Toxikologie |
Genre: | Mathematik, Medizin, Naturwissenschaften, Technik |
Rubrik: | Wissenschaften |
Medium: | Taschenbuch |
Inhalt: | 124 S. |
ISBN-13: | 9783846504055 |
ISBN-10: | 384650405X |
Sprache: | Englisch |
Ausstattung / Beilage: | Paperback |
Einband: | Kartoniert / Broschiert |
Autor: |
Chaudhary, Haresh
Patel, B. N. Patel, D. M. |
Hersteller: | LAP LAMBERT Academic Publishing |
Verantwortliche Person für die EU: | OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, D-66111 Saarbrücken, info@akademikerverlag.de |
Maße: | 220 x 150 x 8 mm |
Von/Mit: | Haresh Chaudhary (u. a.) |
Erscheinungsdatum: | 13.02.2014 |
Gewicht: | 0,203 kg |
Über den Autor
Haresh Chaudhary has completed [...] and [...] from Shri Sarvajanik Pharmacy College,Mehsana and currently working in Formulation Development Department at Cadila Healthcare Ltd, Ahmedabad. He is energetic person with positive attitude toward his goal.
Details
Erscheinungsjahr: | 2014 |
---|---|
Fachbereich: | Toxikologie |
Genre: | Mathematik, Medizin, Naturwissenschaften, Technik |
Rubrik: | Wissenschaften |
Medium: | Taschenbuch |
Inhalt: | 124 S. |
ISBN-13: | 9783846504055 |
ISBN-10: | 384650405X |
Sprache: | Englisch |
Ausstattung / Beilage: | Paperback |
Einband: | Kartoniert / Broschiert |
Autor: |
Chaudhary, Haresh
Patel, B. N. Patel, D. M. |
Hersteller: | LAP LAMBERT Academic Publishing |
Verantwortliche Person für die EU: | OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, D-66111 Saarbrücken, info@akademikerverlag.de |
Maße: | 220 x 150 x 8 mm |
Von/Mit: | Haresh Chaudhary (u. a.) |
Erscheinungsdatum: | 13.02.2014 |
Gewicht: | 0,203 kg |
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