Targeting the Broadly Pathogenic Kynurenin...

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Beschreibung

Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.

Zusammenfassung

Combines basic understanding of the role of the kynurenine pathway with translational applications and clinical relevance

Explains the role of the kynurenine pathway in various disease states

Explores ongoing clinical trials using IDO/TDO inhibitors

Inhaltsverzeichnis

Part I. Overview.- Overview of the Kynurenine Pathway of Tryptophan Metabolism.- Role of Tryptophan Metabolism in Health and Disease.- Nutritional Aspects of Tryptophan Metabolism.- Role of Kynurenine Pathway in Early Brain Development.- Role of Kynurenine Pathway in Aging.- Role of Tryptophan Metabolism in Mood, Behavior, and Cognition.- Part II. Systemic Diseases.- Role of Kynurenine Pathway in Inflammatory Diseases.- Role of Kynurenine Pathway in Allergy.- Role of Kynurenine Pathway in HIV/AIDS.- Role of Kynurenine Pathway in Cardiovascular Disease.- Role of Kynurenine Pathway in Respiratory Diseases.- Role of Kynurenine Pathway in Gastrointestinal Diseases.- Role of Kynurenine Pathway in Insulin Resistance.- Role of Kynurenine Pathway in Infections.- Part III. CNS Disorders.- Role of Kynurenine Pathway in Neurodegenerative Diseases.- Role of Kynurenine Pathway in Epilepsy.- Role of Kynurenine Pathway in Stroke.- Role of Kynurenine Pathway in Pain and Migraines.- Role of Kynurenine Pathway in Autism Spectrum Disorders.- Role of Kynurenine Pathway in Neuropsychiatric Disorders.- Part IV. Oncology.- Role of Kynurenine Pathway in Stem Cell Biology.- Role of Kynurenine Pathway in Cancer Biology.- Role of Kynurenine Pathway in Neuro-oncology.- Role of the Kynurenine Pathway in Hematologic Malignancies.- Part V. Experimental Models and in Vivo Imaging.- Experimental Models to Study the Kynurenine Pathway.- Animal Models to Study the Role of Kynurenine Pathway in Mood, Behavior, and Cognition.- Applications of Small Animal PET Imaging.- Molecular Imaging of Serotonin Synthesis in the Brain.- Molecular Imaging of Tryptophan Metabolism.- Part VI. Therapeutic Approaches.- Inhibition of the Kynurenine Pathway of Tryptophan Catabolism.- Clinical Trials Targeting the Kynurenine Pathway.- The Next Decade in Tryptophan Metabolism Research.

Details

Erscheinungsjahr:	2015
Fachbereich:	Allgemeines
Genre:	Biologie
Rubrik:	Naturwissenschaften & Technik
Thema:	Lexika
Medium:	Buch
Inhalt:	xv 430 S.
ISBN-13:	9783319118697
ISBN-10:	3319118692
Sprache:	Englisch
Herstellernummer:	86372999
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Mittal, Sandeep
Herausgeber:	Sandeep Mittal
Auflage:	1st ed. 2015
Hersteller:	Springer International Publishing Springer International Publishing AG
Maße:	241 x 160 x 28 mm
Von/Mit:	Sandeep Mittal
Erscheinungsdatum:	28.11.2015
Gewicht:	0,915 kg