Joanne Lymn is Professor of Healthcare Education at University of Nottingham, UK, and a National Teaching Fellow.

Alison Mostyn is Professor of Pharmacology Education for Health and Director of Teaching and Learning, University of Nottingham, UK.

Roger Knaggs is Professor of Pain Management at University of Nottingham, UK, and Specialist Pharmacist in Pain Management at Primary Integrated Community Services. He is also President of the British Pain Society.

Michael Randall is Professor of Pharmacology at University of Nottingham, UK, and a Fellow of the British Pharmacological Society.

Dianne Bowskill is Associate Professor of Prescribing Education and Lead for Non-medical prescribing, University of Nottingham, UK.

List of Contributors xxvi

Foreword xxvii

Preface xxviii

Acknowledgements xxix

Section 1 The Patient 1

Section Introduction 1

1 The Consultation 3
Frank Coffey and Dianne Bowskill

2 Accountability and Prescribing 14
Matthew Boyd, Stephanie Bridges, and Helen Boardman

3 Prescribing and the Law 23
Richard Griffith

4 The Ethics of Prescribing 36
Matthew Boyd, Stephanie Bridges, and Helen Boardman

5 Prescribing in Practice 44
Dianne Bowskill and Daniel Shipley

6 Public Health Issues 53
Michael Watson and Katharine Whittingham

Section 2 Pharmacology 63

Section Introduction 65

7 General Principles of Pharmacology 67
Joanne Lymn and Alison Mostyn

8 Pharmacokinetics 1: Absorption and Distribution 79
Joanne Lymn and Alison Mostyn

9 Pharmacokinetics 2: Metabolism and Excretion 92
Joanne Lymn and Alison Mostyn

10 Routes of Administration 106
Joanne Lymn and Roger Knaggs

11 Variations in Drug Handling 114
Michael Randall

12 Polypharmacy and Medicines Optimisation 124
Daniel Shipley

13 Adverse Drug Reactions and Interactions 134
Alison Mostyn and Daniel Shipley

14 Introduction to the Autonomic Nervous System 144
Joanne Lymn

15 Clinical Application of the Principles of the Autonomic Nervous Systems 157
Joanne Lymn

16 The Gastrointestinal System 167
Michael Randall

17 Cardiovascular Drugs and Diseases 177
Richard Roberts

18 Haemostasis and Thrombosis 196
Michael Randall

19 The Renal System 208
Michael Randall

20 The Respiratory System 221
Richard Roberts

21 Introduction to the Central Nervous System 235
Yvonne Mbaki

22 Neurodegenerative Disorders 245
David Kendall

23 Depression and Anxiety 256
Yvonne Mbaki

24 Schizophrenia 267
David Kendall

25 Epilepsy and Antiseizure Drugs 277
Michael F O'Donoghue and Christina Giavasi

26 Pain and Analgesia 293
Roger Knaggs

27 Drugs of Misuse 308
Michael Randall

28 Antibacterial Chemotherapy 315
Tim Hills

29 Antibiotic Resistance and Clostridioides Difficile 331
Tim Hills

30 Antifungal and Antiviral Drugs 342
Tim Hills

31 The Endocrine System 352
Alison Mostyn and Daniel Shipley

32 Contraception and Reproductive Health 369
Alison Mostyn and Anna Soames

33 Cancer Pharmacotherapy 381
Michael Randall

34 Musculoskeletal Disease 392
Sana Awan and David Andrew Walsh

Glossary 409

Activity Answers 417

Index 445