PART I: INTRODUCTION
1 Sepsis: Past, Present, and Futured Lessons From COVID-19
José-Artur Paiva and Jordi Rello
2 Sepsis Definitions: A Historical Perspective
Javier Perez-Fernandez, Arlene C. Torres, and Paola Perez
3 The Epidemiology of Sepsis
Jamila Hedjal
PART II: BASIC CONCEPTS
4 Sepsis Pathophysiology
Maria Jimena Aleman, Luisa Cruz, Jorge Hidalgo, and Allyson Hidalgo
5 Sepsis and Microcirculation
Carlos Enrique A. Orellana Jimenez
6 Genetics and Sepsis
Gabriela Alvarado
PART III: DIAGNOSIS AND MONITORING
7 Early Detection and Screening
Márcio Borges Sá and Rafael Zaragoza Crespo
8 Diagnosis and Monitoring of Sepsis
Pietro Arina and Mervyn Singer
9 Sepsis: Molecular Diagnostics and Biomarkers
John Lyons and Craig Coopersmith
10 Hemodynamic Monitoring: Current Practice and New Perspectives
Christopher Lai and Jean-Louis Teboul
11 Point of Care Ultrasound in the Management of Sepsis
Saad Mahdy, Ahmed F. Hegazy and Tharawt Aisa
12 New Approaches and Understanding of Sepsis
Vanessa Fonseca-Ferrer, Sulimar Morales-Colón, Luis Gerena-Montano, William
Rodríguez-Cintrón, and Gloria M. Rodríguez-Vega
13 Sepsis Quality Indicators in the Emergency Department
Luis Antonio Gorordo-Delsol and Graciela Merinos-Sánchez
PART IV: TREATMENT
14 Sepsis Treatment: Fluids
Michaël Mekeirele, Domien Vanhonacker and Manu L.N.G. Malbrain
15 Vasopressor Therapy in Septic Shock
Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa
16 Mechanical Ventilation in Sepsis
Carlos Sánchez, Orlando Pérez-Nieto and Eder Zamarrón
17 Extracorporeal Membrane Oxygenation for the Support of Patients With Refractory Septic Shock
Jose Alfonso Rubio Mateo-Sidron
18 Antimicrobials in the Management of Sepsis
Judith Jacobi
19 Kidney Support in Sepsis
Javier Maynar, Helena Barrasa, Alex Martin and Fernando Fonseca
20 Hematological Support in Sepsis
Zulmi Aranda, Gerhaldine Morazan and Allyson Hidalgo
21 Specific Treatment of Focus Control in Sepsis
Xavier Guirao, Montserrat Juvany, Clara Centeno and Josep Maria Badia
22 Sepsis Adjunctive Therapies
Javier Perez-Fernandez and Paola Perez
23 Glycemic Control and Stress Ulcer Prophylaxis
Janice L. Zimmerman
24 Nutrition in Sepsis
Victor Sanchez Nava

PART V: SPECIAL SETTINGS
25 Fever in Intensive Care Units
Kazuaki Atagi
26 Sepsis--In the Era of Antimicrobial Resistance
Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa
27 Factors Underlying Racial and Gender Disparities in Sepsis Management
Ryoung-Eun Ko and Gee Young Suh
28 Sepsis in Special Populations
Marie Baldisseri, Laura S. Johnson, Michael Mazzei and Mary Jane Reed
29 Comprehensive Management of Sepsis in Pediatrics
Elisabeth Esteban, Juan Carlos de Carlos, Juan Ignacio Sánchez and Javier Gil Anton
30 Maternal Sepsis
Luis Antonio Gorordo-Delsol, Graciela Merinos- Sánchez, Lucina Nieves-Torres and Jeanette Zúñiga Escorza
PART VI: SPECIAL CONSIDERATIONS
31 Role of Preventive Measures in Sepsis
Jorge Sinclair, Jorge E. Sinclair De Frías and Lorenzo Olivero
32 Value of the Protocolization and Sepsis Performance Improvement Program in Early Identification
Carlos Sanchez
33 Long-Term Sequelae of Sepsis
Ahmed Taha
PART VII: FUTURE OUTLOOK
34 New Diagnostic and Therapeutic Perspectives
Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Erika-Paola Plata Menchaca and Ricard Ferrer
35 Artificial Intelligence in Sepsis
Michiel Schinkel, Ketan Paranjape, Prabath W.B. Nanayakkara and W. Joost Wiersinga