The editors

Simon T. Kudnig, BVSc, MVS, MS, FACVSc, DACVS, is an ACVS Founding Fellow of Surgical Oncology and Referral Surgeon at the Animal Referral Hospital in Victoria, Australia.

Bernard Séguin, DVM, MS, DACVS, is an ACVS Founding Fellow of Surgical Oncology, ACVS Founding Fellow of Oral and Maxillofacial Surgery, and Professor of Surgical Oncology at the Animal Cancer Center at Colorado State University in Fort Collins, Colorado, USA.

List of Contributors xxix Preface xxxii Foreword xxxiii About the Companion Website xxxiv 1 Principles of Surgical Oncology 1William T.N. Culp and Nicole Ehrhart Preoperative Considerations 1 Surgical Planning 2 Postoperative Considerations 12 References 14 2 Multi-modal Therapy 17Tania A. Banks, Christine Mullin, and Craig A. Clifford Introduction 17 Surgery 17 Radiation Therapy 17 Surgery and Radiation 17 Chemotherapy 19 Electrochemotherapy 21 Molecular and Targeted Therapies 21 Complications of Chemotherapy 21 Complications of Radiation Therapy 38 References 41 3 Interventional Oncology 69William T.N. Culp Imaging 69 Instrumentation and Implants 70 Approaches 76 Nonvascular Interventional Oncology Techniques 77 Vascular Interventional Oncology Techniques 81 References 83 4 Skin and Subcutaneous Tumors 92Erik G.H. Wouters, Sebastiaan (Bas) A. van Nimwegen, Stewart Ryan, and Jolle Kirpensteijn Skin Tumors General Principles 92 General Approach to the Diagnosis and Staging of Skin Tumors 93 Treatment Options for Skin Tumors 95 Mast Cell Tumors 98 Mesenchymal Tumors and Melanoma 108 References 128 5 Head and Neck Tumors 143Sara A. Ayres and Julius M. Liptak Lymph Node Staging 143 Nasal Planum Tumors 143 Tumors of the Pinna 148 Tumors of the External Ear Canal 151 Tumors of the Middle Ear 157 Salivary Gland Tumors 162 Tumors of the Lip 167 References 176 6 Oral Tumors 182Julius M. Liptak and B. Duncan X. Lascelles Introduction 182 Diagnosis and Clinical Staging 182 General Surgical Considerations 185 Surgical Approach to Tumors of the Mandible 190 Surgical Approach to Tumors of the Maxilla 207 Mandibular and Maxillary Tumors in Dogs 230 Surgical Approach to Tumors of the Hard Palate 236 Surgical Approach to Tumors of the Tongue 238 Multimodal Management of Oral Tumors 244 Prognosis 246 References 255 7 Alimentary Tract 265William T.N. Culp, Ryan P. Cavanaugh, Earl F. Calfee III, Paolo Buracco, and Tania A. Banks Esophagus 265 Stomach 272 Liver and Gallbladder 282 Pancreas 297 Small Intestine 306 Colorectal Tumors 315 References 373 8 Respiratory Tract and Thorax 393Marina Martano, Sarah Boston, and Emanuela Morello Rhinotomy 393 Laryngeal Tumors 406 Thoracotomy 412 Tracheal Lung 427 Metastasectomy for Sarcomas 444 Thoracic Wall Resection 446 References 456 9 Cardiovascular System 469Simon T. Kudnig and Eric Monnet Heart and Heart-Base Tumors 469 Pericardial Tumors 475 Carotid Body Tumors 476 Vascular Oncologic Surgery - Tumor Thrombus Excision 478 References 480 10 Reproductive System 484Maurine J. Thomson and Tara A. Britt Female Reproductive System 484 Histologic Tumor Types 484 Prognosis 485 Adjuvant Therapy 485 Uterine Tumors 485 Vaginal and Vulvar Tumors 486 Histologic Tumor Types 489 Prognosis 489 Adjuvant Therapy 490 Tumors of the Clitoris 490 Canine Mammary Tumors 490 Feline Mammary Tumors 493 Surgery 493 Male Reproductive System 495 Testicular Tumors 496 Prognosis 498 Prostatic Tumors 498 Surgical Techniques and Outcomes 498 Radiation Therapy 505 Histologic Tumor Types and Prognosis 505 Penile Tumors 505 Surgery 507 References 510 11 Urinary Tract 515Nicholas J. Bacon and James P. Farese Biopsy Procedures for Urinary Tumors 515 Laparoscopy 516 FNA and Needle Core Biopsy 516 Incisional Biopsy 516 Imaging Techniques 517 Kidney 520 Bladder 524 Palliative Procedures 533 References 536 12 Eyelids, Eye, and Orbit 541Cassandra Y. Prpich, B. Duncan X. Lascelles, and Michael Davidson Introduction 541 Clinical Workup and Biopsy Principles 541 Imaging Techniques 542 Eyelid Neoplasia 542 V-plasty and Four-sided Excision 543 Advancement Flap 543 Rotational Flap 545 Semicircular Flap 545 Mucocutaneous Subdermal Plexus Flaps (Lip-to-lid) 546 Bucket Handle or Bridge Flap 546 Conjunctival, Nictitans, and Scleral Neoplasia 551 Eye Neoplasia 554 References 567 13 Endocrine System 569Bernard Séguin and Lisa Brownlee Pituitary Tumors 569 Adrenal Tumors 577 Thyroid Tumors: Feline Hyperthyroidism 589 Thyroid Glands: Canine Thyroid Tumors 595 Parathyroid Tumors 603 Cats 608 Endocrine Pancreatic Tumors 609 References 614 14 Hemolymphatic System 624Deanna R. Worley Lymph Nodes 624 Spleen 639 Thymus 647 Tonsils 657 References 659 15 Nervous System 668Rebecca A. Packer Introduction 668 Clinical Workup 668 Preoperative Imaging Techniques 669 Intracranial and Calvarial Tumors 670 Modifications to Surgical Approaches for Skull Masses 683 Intraoperative Navigation and Imaging Techniques 684 Species Differences 684 Post-Operative Management 685 Vertebral and Spinal Cord Tumors 690 Nerve Sheath Tumors 704 References 712 16 Musculoskeletal Tumors 720Julius M. Liptak, William S. Dernell, Jim P. Farese, and Jonathan P. Bray Osteosarcoma 720 Other Musculoskeletal Tumors 724 Metastatic Tumors of Bone 726 Primary Bone Tumors of Cats 728 Diagnostic Workup 729 Surgical Principles 735 Limb Amputation 736 Hemipelvectomy 743 Adjunctive Therapies 787 References 792 17 Ethics and Surgical Limits of Surgical Oncology 807Julius M. Liptak Introduction 807 Surgical Limits 807 References 813 Index 817