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Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. The updates to the Third Edition include a new section converting "descriptive" data into "predictive" data through comparison to mathematical models, expansion on enzymes, drug metabolites and drug-drug interactions, and two new chapters. The newly developed companion website hosts further educational resources to complement the book. As in previous editions, this new edition includes numerous valuable chapter summaries, detailed references, practical examples, and case studies throughout.
Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. The updates to the Third Edition include a new section converting "descriptive" data into "predictive" data through comparison to mathematical models, expansion on enzymes, drug metabolites and drug-drug interactions, and two new chapters. The newly developed companion website hosts further educational resources to complement the book. As in previous editions, this new edition includes numerous valuable chapter summaries, detailed references, practical examples, and case studies throughout.
2. Drug Affinity and Efficacy
3. Predicting Agonist Effect
4. Drug Antagonism: Orthosteric Drug Effects
5. Allosteric Drug Effects
6. Enzymes as Drug Targets
7. Pharmacokinetics I: Permeation and Metabolism
8. Pharmacokinetics II: Distribution and Multiple Dosing
9. In Vivo Pharmacology
10. Safety Pharmacology
11. The science of Finding Drug Molecules I: Validating and Screening drug targets
12. The Science of Finding Drug Molecules II: Demonstrating Target Engagement and Therapeutic Value
| Erscheinungsjahr: | 2024 |
|---|---|
| Fachbereich: | Toxikologie |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Taschenbuch |
| ISBN-13: | 9780443141249 |
| ISBN-10: | 044314124X |
| Sprache: | Englisch |
| Einband: | Kartoniert / Broschiert |
| Autor: | Kenakin, Terry P |
| Auflage: | 3. Auflage |
| Hersteller: |
Elsevier LTD
Academic Press |
| Maße: | 223 x 150 x 24 mm |
| Von/Mit: | Terry P Kenakin |
| Erscheinungsdatum: | 23.05.2024 |
| Gewicht: | 0,73 kg |
2. Drug Affinity and Efficacy
3. Predicting Agonist Effect
4. Drug Antagonism: Orthosteric Drug Effects
5. Allosteric Drug Effects
6. Enzymes as Drug Targets
7. Pharmacokinetics I: Permeation and Metabolism
8. Pharmacokinetics II: Distribution and Multiple Dosing
9. In Vivo Pharmacology
10. Safety Pharmacology
11. The science of Finding Drug Molecules I: Validating and Screening drug targets
12. The Science of Finding Drug Molecules II: Demonstrating Target Engagement and Therapeutic Value
| Erscheinungsjahr: | 2024 |
|---|---|
| Fachbereich: | Toxikologie |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Taschenbuch |
| ISBN-13: | 9780443141249 |
| ISBN-10: | 044314124X |
| Sprache: | Englisch |
| Einband: | Kartoniert / Broschiert |
| Autor: | Kenakin, Terry P |
| Auflage: | 3. Auflage |
| Hersteller: |
Elsevier LTD
Academic Press |
| Maße: | 223 x 150 x 24 mm |
| Von/Mit: | Terry P Kenakin |
| Erscheinungsdatum: | 23.05.2024 |
| Gewicht: | 0,73 kg |
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